Studies in the Caron Lab are focused on elucidating unique G protein-coupled receptor pathways that are important for the development and function of the cardiovascular system. Using a variety of gene-targeted animal models in conjunction with state-of-the-art in vitro cell biological systems, we have discovered fundamental roles for several secretin- and chemokine-family receptors in cardiovascular development and disease. Much of our recent work has focused on the pivotal roles that RAMPs (receptor activity-modifying proteins) play in controlling receptor function, cellular signaling, and physiology. The importance of the RAMP-receptor interaction is best exemplified by our work centered on the small blood protein, adrenomedullin – a potent lymphangiogenic vasodilator that serves as a strong prognostic indicator for many disease conditions.
NOW HIRING!! We are looking for a Postdoctoral Scholar to study mechanisms of G protein-coupled receptor (GPCR) interactions with receptor activity modifying proteins (RAMPs). APPLY HERE!!!!
- Cell Biology & Physiology Department
- Genetics Department
- UNC McAllister Heart Institute
- Lineberger Comprehensive Cancer Center
- Integrative Vascular Biology Program
- Center for Gastrointestinal Biology and Disease
- Curriculum in Cell Biology and Physiology
- Curriculum in Genetics and Molecular Biology