Journal Covers from the Caron Lab
Most Recent Publications
2025:
Flavored e-cigarettes modulate embryo development, fetal growth, and potentiate early fetal demise without nicotine. Marbrey MW, Cripps SM, Huang R, Kistner BM, Somany A, Douglas ES, Caron KM. Commun Med (Lond). 2025 Aug 28;5(1):373. doi: 10.1038/s43856-025-01094-0. PMID: 40877576
Receptor activity-modifying protein 3 enhances GLP-1-mediated insulin secretion. Pearce A, Kumari P, Sisk CM, Harris M, Yeung HY, Winfield S, Caron KM, Ladds G. J Biol Chem. 2025 Aug 18;301(10):110604. doi: 10.1016/j.jbc.2025.110604. Online ahead of print. PMID: 40835007
Lymphatic Activation of ACKR3 Signaling Regulates Lymphatic Response After Ischemic Heart Injury. Balint L, Patel S, Serafin DS, Zhang H, Quinn KE, Aghajanian A, Kistner BM, Caron KM. Arterioscler Thromb Vasc Biol. 2025 May;45(5):754-768. doi: 10.1161/ATVBAHA.124.322288. Epub 2025 Mar 27. PMID: 40143814
Morphology of the glymphatic and meningeal lymphatic structures of the bottlenose dolphin. Keenan TF, Jackson ON, Nelson-Maney NP, Rommel SA, McLellan WA, Pabst DA, Costidis AM, Caron KM, Kernagis DN, Rotstein DS, Braun M, Tift MS. Sci Rep. 2025 Aug 18;15(1):30216. doi: 10.1038/s41598-025-14840-0. PMID: 40825973
Taking a Cellular TRP Around the Lymphatic Collectors. Caron KM.
Arterioscler Thromb Vasc Biol. 2025 Sep;45(9):1519-1520. doi: 10.1161/ATVBAHA.125.323058. Epub 2025 Aug 7. PMID: 40772297
AHR activated placental adrenomedullin: A plausible factor in smoke-induced preeclampsia protection. Marbrey MW, Kistner B, Douglas ES, Caron KM. Placenta. 2025 Jun 26;167:175-180. doi: 10.1016/j.placenta.2025.05.013. Epub 2025 May 15. PMID: 40408837
Meningeal Lymphatic and Glymphatic Structures in a Pelagic Delphinid (Delphinus delphis). Jackson ON, Keenan TF, Nelson-Maney NP, Rommel SA, McLellan WA, Pabst DA, Costidis AM, Caron KM, Kernagis DN, Rotstein DS, Thayer VG, Harms CA, Piscitelli-Doshkov MA, Doshkov P, Schweikert LE, Yopak KE, Braun M, Tift MS. Animals (Basel). 2025 Mar 4;15(5):729. doi: 10.3390/ani15050729. PMID: 40076012
2024:
Cardiac lymphatics undergo distinct remodeling during hypertrophic and nonhypertrophic pregnancy. Kistner BM, Tian Y, Douglas ES, Caron KM.
Am J Physiol Heart Circ Physiol. 2024 Nov 1;327(5):H1155-H1161. doi: 10.1152/ajpheart.00459.2024. Epub 2024 Sep 13. PMID: 39269453
Proximity interactome of lymphatic VE-cadherin reveals mechanisms of junctional remodeling and reelin secretion. Serafin DS, Harris NR, Bálint L, Douglas ES, Caron KM. Nat Commun. 2024 Sep 4;15(1):7734. doi: 10.1038/s41467-024-51918-1. PMID: 39232006.
Presynaptic sensor and silencer of peptidergic transmission reveal neuropeptides as primary transmitters in pontine fear circuit.
Kim DI, Park S, Park S, Ye M, Chen JY, Kang SJ, Jhang J, Hunker AC, Zweifel LS, Caron KM, Vaughan JM, Saghatelian A, Palmiter RD, Han S. Cell. 2024 Sep 5;187(18):5102-5117.e16. doi: 10.1016/j.cell.2024.06.035. Epub 2024 Jul 22. PMID: 39043179
Meningeal lymphatic CGRP signaling governs pain via cerebrospinal fluid efflux and neuroinflammation in migraine models. Nelson-Maney NP, Bálint L, Beeson AL, Serafin DS, Kistner BM, Douglas ES, Siddiqui AH, Tauro AM, Caron KM. J Clin Invest. 2024 May 14;134(15):e175616. doi: 10.1172/JCI175616.
G protein-coupled estrogen receptor (GPER)/GPR30 forms a complex with the β1-adrenergic receptor, a membrane-associated guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells. Tutzauer J, Serafin DS, Schmidt T, Olde B, Caron KM, Leeb-Lundberg LMF. Arch Biochem Biophys. 2024 Feb;752:109882. doi: 10.1016/j.abb.2024.109882. Epub 2024 Jan 10. PMID: 38211639
2023:
Clinical Potential of Adrenomedullin Signaling in the Cardiovascular System. Bálint L, Nelson-Maney NP, Tian Y, Serafin SD, Caron KM. Circ Res. 2023 Apr 28;132(9):1185-1202. doi: 10.1161/CIRCRESAHA.123.321673. Epub 2023 Apr 27.
Coumestrol induces oxidative stress and impairs migration and embryonic growth. Marbrey MW, Douglas ES, Goodwin ER, Caron KM. Reproduction. 2023 May 15;166(1):1-11. doi: 10.1530/REP-23-0017. Print 2023 Jul 1.
The ebb and flow of cardiac lymphatics: a tidal wave of new discoveries. Harris NR, Bálint L, Dy DM, Nielsen NR, Méndez HG, Aghajanian A, Caron KM. Physiol Rev. 2023 Jan 1;103(1):391-432. doi: 10.1152/physrev.00052.2021. Epub 2022 Aug 11.
2022:
Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development. Xu W, Nelson-Maney NP, Bálint L, Kwon HB, Davis RB, Dy DCM, Dunleavey JM, St Croix B, Caron KM. Int J Mol Sci. 2022 May 20;23(10):5712. doi: 10.3390/ijms23105712.
Characterization of Antibodies against Receptor Activity-Modifying Protein 1 (RAMP1): A Cautionary Tale. Hendrikse ER, Rees TA, Tasma Z, Garelja ML, Siow A, Harris PWR, Pawlak JB, Caron KM, Blakeney ES, Russo AF, Sowers LP, Lutz TA, Le Foll C, Walker CS, Hay DL. Int J Mol Sci. 2022 Dec 16;23(24):16035. doi: 10.3390/ijms232416035. PMID: 36555690
Endocardium-to-coronary artery differentiation during heart development and regeneration involves sequential roles of Bmp2 and Cxcl12/Cxcr4. D’Amato G, Phansalkar R, Naftaly JA, Fan X, Amir ZA, Rios Coronado PE, Cowley DO, Quinn KE, Sharma B, Caron KM, Vigilante A, Red-Horse K. Dev Cell. 2022 Nov 21;57(22):2517-2532.e6. doi: 10.1016/j.devcel.2022.10.007. Epub 2022 Nov 7. PMID: 36347256
Dermal Lymphatic Capillaries Do Not Obey Murray’s Law. Talkington AM, Davis RB, Datto NC, Goodwin ER, Miller LA, Caron KM. Front Cardiovasc Med. 2022 Apr 12;9:840305. doi: 10.3389/fcvm.2022.840305.
Accelerated Development With Increased Bone Mass and Skeletal Response to Loading Suggest Receptor Activity Modifying Protein-3 as a Bone Anabolic Target. Pacharne S, Livesey M, Kadmiel M, Wang N, Caron KM, Richards GO, Skerry TM. Front Endocrinol (Lausanne). 2022 Jan 12;12:807882. doi: 10.3389/fendo.2021.807882.
VE-Cadherin Is Required for Cardiac Lymphatic Maintenance and Signaling. Harris NR, Nielsen NR, Pawlak JB, Aghajanian A, Rangarajan K, Serafin DS, Farber G, Dy DM, Nelson-Maney NP, Xu W, Ratra D, Hurr SH, Qian L, Scallan JP, Caron KM. Circ Res. 2022 Jan 7;130(1):5-23. doi: 10.1161/CIRCRESAHA.121.318852. Epub 2021 Nov 18.